Biochemical evaluation of vitamin D levels in pre diabetes, type 2 diabetes mellitus and its correlation with glycated hemoglobin

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Original Article

Author Details : Suresh Nayak B, Ajit Thakur*, Gayathri L, Prithvi Nayak

Volume : 5, Issue : 4, Year : 2018

Article Page : 474-477

https://doi.org/10.18231/2394-2126.2018.0110

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Abstract

Introduction: Globally, 1 billion people are suffering with deficiency or insufficiency of vitamin D. Vitamin D deficiency is also associated with metabolic disorders. This study evaluates Vitamin D levels in prediabetes, T2DM patients and its correlation with HbA1c.
Materials and Methods: This study was done in Department of Physiology in association with Department of Endocrinology, JNU Institute of Medical Sciences & Research Center, Jaipur. A total of 155 subjected were enrolled into the study. They were divided into three groups, 65 age and gender matched healthy subjects were taken as group I (controls) (HbA1c: 5.5 to 6.5 %), 45 prediabetic subjects were taken as group II (HbA1c: 6.5 to 7.5 %) and 45 T2DM subjects were taken as group III (HbA1c: >7.5%). Age of the study subjects was 45 to 65 years. Serum sample was used for the estimation of random sugar (GOD-POD method) by using ERBA chemistry analyzer, vitamin D by ELISA method, using mini VIDAS and EDTA sample for HbA1c by using BIORAD D10.
Results: In this study, random blood sugar and HbA1c levels were significantly elevated in pre diabetic (group II), T2DM (group III) subjects compared with controls (group I). Significant reduction was observed in prediabetic, T2DM subjects compared to controls in respect to vitamin D levels. Negative correlation was observed between HbA1c and vitamin D.
Conclusion: In conclusion, the results of this study showed, significant reduction and negative correlation between serum vitamin D levels and HbA1c in prediabetic and T2DM patients. This study results indicates that there may be need to screen pre diabetic and T2DM patients with poor glycemic control for Vitamin D status.

Keywords: Glycated hemoglobin, Glycemic control, T2DM, Vitamin D deficiency.

How to cite : Suresh Nayak B, Thakur A, Gayathri L, Nayak P, Biochemical evaluation of vitamin D levels in pre diabetes, type 2 diabetes mellitus and its correlation with glycated hemoglobin. Indian J Clin Anat Physiol 2018;5(4):474-477

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