Evaluation of cardiac autonomic functions of non diabetic offsprings of diabetic parents

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Original Article

Author Details : Mehak Mufti, Ravikiran Kisan, D.V. Deshpande

Volume : 5, Issue : 3, Year : 2018

Article Page : 389-393

https://doi.org/10.18231/2394-2126.2018.0090

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Abstract

Occurrence of autonomic imbalance is not very uncommon in diabetic patients and evidences of subclinical autonomic imbalance in their offsprings are also reported.
Objective: To study the effect of parental diabetes on cardiac autonomic functions of their non diabetic children.
aterials and Methods: The study was conducted in the department of Physiology SSIMS and RC, Davangere, after the approval of the institutional ethical committee, on 100 subjects. 50 non diabetic offsprings of diabetic parents (cases) and 50 non diabetic offsprings of non diabetic parents (controls). The subjects were in the age group of 18-25 years and were selected on the basis of predetermined inclusion exclusion criteria. The study protocol was explained and informed written consent was taken from the subjects. Battery of six conventional cardiac autonomic function tests were done which included, resting HR, HR response to deep breathing, HR response to Valsalva, DBP response to IGHT, BP and HR response to change in posture, BP response to CPT. Statistical analysis was done using Student’s unpaired t test.
Result: Our results show decreased parasympathetic activity as indicated by increased basal HR (p< 0> Conclusion: Our results show that there is a state of sympathovagal imbalance in the non diabetic offsprings of diabetic parents that can be inferred from an increased sympathetic activity and decreased parasympathetic activity.

Keywords: Diabetes mellitus, Autonomic function.

How to cite : Mufti M, Kisan R, Deshpande D, Evaluation of cardiac autonomic functions of non diabetic offsprings of diabetic parents. Indian J Clin Anat Physiol 2018;5(3):389-393

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