Evaluation of diuretic activity of Lagenaria Siceraria in Albino rats

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Original Article

Author Details : K. Harini, T. Jayasree

Volume : 2, Issue : 3, Year : 2017

Article Page : 99-103

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Abstract

Lagenaria siceraria belongs to Cucurbitaceae family. It is commonly known as lauki (Hindi) and bottle gourd (English) is a medicinal plant. It is used as medicine for its cardio tonic, general tonic and diuretic properties.
The present study was aimed to evaluate the diuretic activity of Lagenaria siceraria in comparison to Hydrochlorothiazide. 5 groups of rats with 6 rats in each group were taken.1^st group of 6 rats was kept as control. 2^nd group of 6 rats were fed with standard hydrochlorothiazide. The Third, fourth and fifth groups of 6 rats each were taken as test groups and administered with the crude extract of LAGENARIA SICERARIA in doses of 100, 200 and 400mg/kg body weight. The urine was collected for a period of 5 hours and 24 hours. Urinary volume, urinary electrolytes namely sodium, potassium and chloride are estimated.
The results obtained in the study indicate that Aqueous Extract of Lagenaria siceraria(AELS) increases the excretion of 3 parameters i.e. urinary volume, urinary Na⁺, urinary Cl^- which is statistically significant and comparable to that of the standard diuretic agent hydrochlorothiazide and decrease K⁺excreation.

Keywords: Lagenaria siceraria, Hydrochlorothiazide, Diuretic activity, Urinary volume, Urinary Na⁺, k⁺, Cl^- excretion

How to cite : Harini K, Jayasree T, Evaluation of diuretic activity of Lagenaria Siceraria in Albino rats. Indian J Clin Anat Physiol 2017;2(3):99-103

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