Memory enhancing activity of Momordica charantia by scopolamine induced amnesia in rats


Original Article

Author Details : Ankur Joshi, Priyanka Soni, Sapna Malviya, Anil Kharia

Volume : 2, Issue : 1, Year : 2017

Article Page : 11-18


Suggest article by email

Get Permission

Abstract

The present study was undertaken to investigate the effect of Momordica charantia on cognitive functions, total cholesterol levels and cholinesterase (ChE) activity in scopolamine-induced amnesia in rats. The paste of Momordica charantia was administered orally at three doses (150, 300 and 600 mg/kg) for 7 and 14 consecutive days to the respective groups of rats. Piracetam (200 mg/kg) was used as a standard nootropic agent. Learning and memory parameters were evaluated using elevated plus maze (EPM), passive avoidance and motor activity paradigms. Brain ChE activity and serum biochemical parameters like total cholesterol, total triglycerides and glucose were evaluated. It was observed that Momordica charantia at the above-mentioned doses after 7 and 14 days of administration in the respective groups significantly reversed scopolamine (1 mg/kg i.p.)-induced amnesia, as evidenced by a decrease in the transfer latency in the EPM task and step-down latency in the passive avoidance task. Momordica charantia reduced the brain ChE activity in rats. Momordica charantia also exhibited a remarkable cholesterol and triglyceride lowering property and slight increase in glucose levels in the present study.

Keywords: Alzheimer’s disease, Amnesia, Momordica charantia, Scopolamine


How to cite : Joshi A, Soni P, Malviya S, Kharia A, Memory enhancing activity of Momordica charantia by scopolamine induced amnesia in rats. Indian J Clin Anat Physiol 2017;2(1):11-18


This is an Open Access (OA) journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.







View Article

PDF File  


Copyright permission

Get article permission for commercial use

Downlaod

PDF File    






Article Access statistics

Viewed: 1760

PDF Downloaded: 522