Consequences of sub acute administration of aqueous extract of Terminalia belerica fruit pulp on controlling anxiety in swiss albino mice

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Original Article

Author Details : Poovizhi Bharathi R, Mohandas Rai, Manohar VR

Volume : 1, Issue : 1, Year : 2016

Article Page : 30-34

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Abstract

Background: The objective was to find the consequence of sub acute administration of Aqueous extract of Terminalia belerica fruit pulp (AETBFP) on controlling anxiety by using Dark and light arena and Elevated plus maze test.
Methods: Five groups of naive male Swiss albino mice were used. Each group had six animals. I Group received 1% Gum acacia suspension 3ml/kg orally(vehicle); II Group received Diazepam 1mg/kg orally (standard drug) and III, IV and V Groups received AETBFP 9, 18 and 36 mg/kg (test drug) orally respectively once daily for ten days. On tenth day one hour after administering the drug, the anxiolytic activity was evaluated using screening methods. The parameters observed in dark and light arena are number of entries, duration of stay and rears in light arena. The parameters observed in elevated plus maze test are number of entries, time spent and rears in open arm. Percentage ratio of open/total arm entries was calculated. Appropriate statistical analysis was carried on.
Results: When compared to control group, AETBFP (36mg/kg) group showed significant increase in number of entries and duration of stay in light arena in dark and light arena model. When compared to control group, AETBFP (18mg/kg and 36mg/kg) groups showed significant increase in number of entries, time spent in open arm and percentage ratio of open/total arm entries in elevated plus maze model.
Conclusions: The study has shown that sub acute administration of AETBFP at a dose of 18mg/kg and 36mg/kg had significant control on anxiety.

Keywords: Dark and light arena, Diazepam, Elevated plus-maze, Gum acacia, Swiss albino mice, Terminalia belerica

How to cite : Poovizhi Bharathi R, Rai M, Manohar Vr, Consequences of sub acute administration of aqueous extract of Terminalia belerica fruit pulp on controlling anxiety in swiss albino mice. Indian J Clin Anat Physiol 2016;1(1):30-34

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