Attenuation of depression by Areca catechu ethanol extract in swiss albino mice

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Original Article

Author Details : Srinivas Bhat U, Mohandas Rai, Sharath Kumar Krishna, Rashmi Rao

Volume : 1, Issue : 1, Year : 2016

Article Page : 1-4

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Abstract

Background: Mood or affective disorder is psychological manifestations, depression is now known as a complex disorder involving the whole body and the diagnosis of depression is based on a heterogeneous set of symptoms.
Objectives: To evaluate antidepressant activity of Areca catechu Ethanol Extract in Swiss Albino Mice.
Materials and Methods: Adult Swiss albino mice were selected and randomly divided in to five groups as control which received normal saline, standard which received Imopramine 10mg/kg and three test groups which received Areca catechu ethanol extract at the dose of 40, 80 and 160 mg/kg respectively. All the drugs were administered intraperitonially (0.1ml/10gm) 30 minutes hour before the experiment followed by testing with forced swim test and tail suspension test successively to note the duration of immobility with the observation as mean± SD and was compared with the control by using ANOVA followed by Dunnets test. p<0.05 was considered as significant.
Conclusion: We found that, acute treatment with Areca catechu ethanol extract at the dose of 80mg/kg and at the dose of 40 and 80mg/kg has shown significant antidepressant action by forced swim test and tail suspension test respectively

How to cite : Srinivas Bhat U, Rai M, Krishna S K, Rao R, Attenuation of depression by Areca catechu ethanol extract in swiss albino mice. Indian J Clin Anat Physiol 2016;1(1):1-4

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