The role of the lymphatic system in brain clearance mechanisms implications for neurodegenerative disorders

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Review Article

Author Details : Anand Singh Chouhan*, Sumit Kumar, Meena Rathore, Hemant Kumar, Manshi Saxsena

Volume : 11, Issue : 4, Year : 2024

Article Page : 205-210

https://doi.org/10.18231/j.ijcap.2024.044

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Abstract

The lymphatic system, traditionally associated with immune surveillance and fluid homeostasis, has emerged as a pivotal player in maintaining brain health. Recent discoveries highlight the brain’s unique clearance mechanisms, particularly the glymphatic system and meningeal lymphatic vessels, in removing metabolic waste and facilitating neuroimmune communication. Dysfunction in these pathways has been implicated in the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS). This review explores the anatomy and physiology of the lymphatic system in the brain, its role in waste clearance, and its implications for neurodegenerative disorders, drawing on recent advances in imaging and molecular research.
 

Keywords: Neurodegenerative disorders, Cerebrospinal fluid, Lymphatic system.

How to cite : Chouhan A S, Kumar S, Rathore M, Kumar H, Saxsena M, The role of the lymphatic system in brain clearance mechanisms implications for neurodegenerative disorders. Indian J Clin Anat Physiol 2024;11(4):205-210

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